* US GDP, jobless claims data disappoint investors
* Big manufacturers, Exxon Mobil weigh on the Dow
* Biotechs lift Nasdaq on deal news
* Dow off 1 pct, S&P 500 off 0.6 pct, Nasdaq up 0.5 pct (Updates to afternoon, changes byline)
By Steven C. Johnson
NEW YORK, July 31 (Reuters) - The Dow industrials and the S&P 500 fell on Thursday as disappointing growth and employment data heightened concerns about the economy's health and the outlook for corporate profits.
But news of a proposed buyout of ImClone Systems Inc <IMCL.O> buoyed biotechnology shares, keeping the Nasdaq in positive territory.
Investors unloaded some shares of big manufacturers, including Caterpillar Inc <CAT.N>, down nearly 3 percent, and Boeing Co <BA.N>, off more than 2 percent.
Data showing weaker-than-expected second-quarter growth and a rise in the number of Americans applying for jobless benefits soured market sentiment a day before the government is due to release its closely watched July payrolls report.
A profit miss for Exxon Mobil Corp <XOM.N> drove the energy giant's stock down 3 percent and was a top drag on both the Dow and the S&P 500. For details, see [
]"Investors are on edge," said Alan Lancz, president of Alan B. Lancz & Associates Inc., an investment advisory firm, based in Toledo, Ohio. "This morning's economic numbers were disappointing. Unemployment is a concern. The economy is still growing but it's definitely slow growth."
The Dow Jones industrial average <
> was down 113.58 points, or 0.98 percent, at 11,470.11. The Standard & Poor's 500 Index <.SPX> was down 7.96 points, or 0.62 percent, at 1,276.30. The Nasdaq Composite Index < > was up 12.29 points, or 0.53 percent, at 2,342.01.The Nasdaq rose after Bristol-Myers Squibb Co <BMY.N> offered to buy out the remaining stake in biotech partner ImClone. For details, see [
]. ImClone shares notched their biggest one-day advance in 13 years, up 37.2 percent at $63.69.But on the New York Stock Exchange, Exxon Mobil's shares slid to $81.78, while those of Caterpillar, the maker of excavators and bulldozers, fell to $70.01. Shares of plane maker Boeing <BA.N> declined 2.3 percent to $62.20.
Shares of ConocoPhillips <COP.N> and Chevron <CVX.N> fell about 2 percent as oil prices <CLc1> dropped more than $2 a barrel.
Walt Disney <DIS.N>, a Dow component, shed 3.9 percent to $30.45 after the company said park bookings were flat.
Cleveland Rueckert, a research associate at Birinyi Associates in Stamford, Connecticut, said some of the losses were the result of investors taking profits at month-end.
But the economic data also did little to lift investors' spirits. Government data showed the U.S. economy grew at a 1.9 percent annual rate in the second quarter, below the 2 percent reading forecast by analysts in a Reuters poll.
According to another report, the number of U.S. workers filing new claims for jobless benefits jumped 44,000 last week, above the Wall Street consensus. [
]But another key indicator showing business activity in the U.S. Midwest rose unexpectedly in July. [
]Analysts polled by Reuters expect Friday's payrolls data to show the economy shed another 75,000 jobs in July. Strategists, though, said a better number could spark a market rally, especially after a separate report from ADP Employment Services on Wednesday showed a surprising increase in private-sector jobs in July.
"If payrolls beats expectations, I would expect a very strong day in the market," Rueckert said. (Additional reporting by Ellis Mnyandu; Editing by Jan Paschal)