* FTSEurofirst 300 closes 0.1 pct higher
* Index rises 3.3 pct over the week, biggest gain in 6 mths * Uncertainty persists on Portugal, euro zone debt
By Brian Gorman
LONDON, March 25 (Reuters) - European shares edged up on Friday, and recorded their biggest weekly gain in six months, with investors increasingly confident Japan's nuclear crisis and Middle East unrest would not derail global growth.
The pan-European FTSEurofirst 300 <
> index of top shares rose 0.1 percent to 1,124.65 points, the highest close since March 10. Volumes were 77.5 percent of the 90-day average. Over the week, the index rose 3.3 percent, the biggest gain since September, and has regained almost half the ground lost in the fall between a February high and a March low.Drugmakers <.SXDP> were among the gainers, with investors lured by cheap valuations. The sector is still down more than 4 percent in the year to date, compared with a 0.3 percent gain for the pan-European benchmark.
Heavyweights GlaxoSmithKline <GSK.L>, AstraZeneca <AZN.L> and Sanofi-Aventis <SASY.PA> rose between 0.9 and 1.2 percent.
News that the U.S. economy is growing more quickly than previously estimated also helped shares. [
]Stock markets worldwide have benefited from monetary stimulus. But some strategists say some momentum might be lost in the run-up to the end of the Federal Reserve's second round of quantitative easing in June.
"As people anticipate the finishing of QE2, it could be a challenging time. The last time the Fed turned off the printing presses, the markets had a tough time," said Andy Lynch, who managers 2.5 billion euros ($3.50 billion) for Schroders.
He added: "We will see interest rate rises, though it's not the right thing to do."
Fund managers also pointed to continued uncertainty in the peripheral economies of the euro zone. European leaders agreed a new package of anti-crisis measures at a two-day summit, but were forced to delay increasing their rescue fund and acknowledged they faced new threats from a government collapse in Portugal. [
]Economists suggested Portuguese yields were above sustainable levels and a bailout was likely. [
]"The market was being helped by good company results and positive outlook statements; investors have been buying on dips," said Colin McLean, managing director at fund group SVM Asset Management in Edinburgh, which has 630 million pounds ($1.01 billion) assets under management.
"However, Europe's issues are still not resolved, and going into the second quarter there could be some weakness."
Across Europe, Britain's FTSE 100 <
>, Germany's DAX < > and France's CAC40 < > rose between 0.1 and 0.3 percent. Portugal's benchmark < > and Spain's IBEX <>IBEX> fell 0.2 and 0.4 percent, respectively.
BP RISES
BP <BP.L> recovered from earlier falls to close 0.6 percent higher. Russia's Rosneft <ROSN.MM> vowed to push ahead with a strategic alliance with BP, despite a block on the deal by the British oil company's partners in joint venture TNK-BP [
].On the downside, Autonomy <AUTN.L> slipped 3.4 percent after JPMorgan downgraded the software firm's 2012 earnings estimates.
Thomson Reuters Datastream figures showed the STOXX Europe 600 <
> index priced at 10.2 times forecast earnings, below a 10-year average of 13.6, while the S&P 500 <.SPX> has a one-year forward price-earnings ratio of 12.5 times.Some analysts suggested higher dividends would also tempt investors back into the market.
"With investors quite keen to persuade company management to return more cash to them, I think dividend growth, in aggregate, could surprise slightly to the upside," said Ian Williams, strategist at Altium Securities. ($1=.6217 pounds) (Additional reporting by Joanne Frearson; Editing by Will Waterman)