* FTSEurofirst 300 index falls 2.2 pct
* ECB cuts rates to 1.5 pct, BoE cuts to 0.5 pct
* Banks, commodities fall
By Joanne Frearson
LONDON, March 5 (Reuters) - European shares were lower at midday on Thursday after the ECB cut its key lending rate to a record low of 1.5 percent and the Bank of England cut to 0.5 percent, another record, and fears over General Motors' <GM.N> future weighed.
By 1302 GMT the pan-European FTSEurofirst 300 <
> index of top shares was down 2.2 percent at 681.06 points. The index is down around 17 percent for the year.The European Central Bank cut its benchmark rate by 50 basis points to 1.5 percent.
"The cut is in line with expectations. But it should be some time for another cut as policy makers will need to see how the liquidity and global stimulus packages work before they reconsider doing anything else," said Heino Ruland, strategist at Ruland Research.
Earlier the Bank of England's Monetary Policy Committee (MPC) cut its key rate by another 50 basis points to a record low of 0.5 percent, and said it would buy assets worth 75 billion pounds ($106 billion) in a drive to help the British economy by expanding the money supply. [
]"The MPC has acknowledged the cuts may still not be enough and now has moved on to quantitative easing. Buying assets worth 75 billion sterling could be a positive sign," said Mike Lenhoff, strategist at Brewin Dolphin.
But bank and commodity shares were the top losers.
Barclays <BARC.L> was down 12.9 percent after broker Panmure said it would face "major losses" this year and next due to risks related to its exposure to structured credit and monoline insurers.
HSBC <HSBA.L>, Credit Suisse <CSGN.VX>, Banco Santander <SAN.MC> were all down by between 3.3 and 5.7 percent.
British Life insurer Aviva <AV.L> slipped 28.7 percent as analysts cited concerns over the company's capital strength after the group said it will maintain its dividend.
Energy stocks were lower as crude <Clc1> fell 3.4 percent after surging nearly 9 percent overnight. BG Group <BG.L>, BP <BP.L>, Royal Dutch Shell <RDSb.L> and Total <TOTF.PA> were down 0.5-3.6 percent.
Miners also fell, with Anglo American <AAL.L> down 6.3 percent and Rio Tinto <RIO.L> down 5.9 percent.
Across Europe, the FTSE 100 <
> index was down 2.2 percent, Germany's DAX < > was 2.5 percent lower and France's CAC 40 < > was down 2 percent.GM WORRIES; DRUGMAKERS, GDF SUEZ RISE
General Motors spooked investors by saying it had substantial doubt about its ability to continue as a going concern if it fails to stem its losses and generate cash, and it may be forced to file for bankruptcy.
As investors sought sanctuary, drugmakers were the top risers. GlaxoSmithKline <GSK.L>, Novartis <NOVN.VX>, Roche <ROG.VX> were up 0.5-4.7 percent.
French utility GDF Suez <GSZ.PA> gained 4 percent after reporting higher 2008 profits and stepped up cost-cutting efforts to brace for an economic downturn that has pushed energy prices sharply lower. [
]UK property firm Hammerson <HMSO.L> jumped 6.2 percent after its 584 million-pound rights issue, announced last month to pay down debt and strengthen its balance sheet, was seen to be well-received.
But German steelmaker Salzgitter <SZGG.DE> fell 11.5 percent on the back of weaker than expected 2008 results and a grim outlook for 2009.
The BoE and ECB cuts come at a time when worries over the economy are intensifying in Europe.
Euro zone GDP figures confirmed that Europe shrank 1.5 percent in October-December after a 0.2 percent drop the previous quarter.
"The interesting aspect in the breakdown of the data is falling consumer spending, which is quite significant. This suggests Q1 could be as bad as Q4, 2008," said Luigi Speranza at BNP Paribas.
On Friday investors will get the U.S. non-farm payrolls jobs data, due out at 1330 GMT.
Bernard McAlinden, strategist at NCB Stockbrokers, said: "The markets will look for some stabilisation in the U.S, non-farm payrolls ... That's as much as you can hope for. There are major doubts about whether the goverment actions will work." ($1=.7071 pounds) (Additional reporting by Brian Gorman; Editing by Greg Mahlich) (joanne.frearson@thomsonreuters.com; +44 207 542 2773, Reuters Messaging:joanne.frearson.thomsonreuters.com@reuters.net)