* Uncertainty about bailout plan weighs on stocks
* Oil rises on bank rescue effort, weak dollar
* Japanese bank plans to buy big stake in Morgan Stanley
* Dow off 2.2 pct, S&P off 2.4 pct, Nasdaq off 2.7 pct (Updates to afternoon, changes byline)
By Steven C. Johnson
NEW YORK, Sept 22 (Reuters) - U.S. stocks fell on Monday as a spike in oil prices renewed fear about consumer spending and investors worried whether a $700 billion rescue package for the financial sector would be enough to resuscitate the economy.
Oil rose 12 percent -- the biggest jump in 10 years -- to $117.28 <CLc1>, extending a rally sparked by Friday's announcement of the banking rescue plan and a fall in the dollar.
Banks, home builders, retailers, airlines and big manufacturers were among the biggest decliners as negotiations over the plan to mop up bad mortgage debt on banks' balance sheets heated up in Washington.
The Bush administration is pressing Congress to approve one of the costliest U.S. bailouts for financial companies since the Great Depression.
Shares of JPMorgan Chase <JPM.N> , the No 3 U.S. bank, slid 10.3 percent to $42.22, making the stock the top drag on both the Dow and the S&P 500.
Wells Fargo <WFC.N> , the fifth-largest U.S. bank, fell 12.1 percent to $34.98. The S&P financial index <.GSPF> declined more than 7 percent.
Monday's malaise reversed a rally on Friday when the bailout announcement sparked Wall Street's best one-day gain since 1987.
"Here it is Monday and people are waking up from a gigantic hangover, trying to figure out what's next," said John Schloegel, vice president of investment strategies for Capital Cities Asset Management in Austin, Texas.
"There's pain ahead for the economy, pain for the consumer, pain at the gas pump," he said. "We're getting hit with a double whammy today with commodities moving higher."
The Dow Jones industrial average <
> was down 251.68 points, or 2.21 percent, at 11,136.76. The Standard & Poor's 500 Index <.SPX> was down 30.78 points, or 2.45 percent, at 1,224.30. The Nasdaq Composite Index < > was down 60.23 points, or 2.65 percent, at 2,213.67."There is lingering uncertainty about the overall economy despite the moves to shore up the financial markets," said Michael James, senior trader at regional investment bank Wedbush Morgan in Los Angeles.
"Clearly the weakness in the financial markets has been part of the drag on the economy in the first nine months, but it has not been the only drag. Merely shoring up the weak financial markets is not necessarily a salve to the overall economy's problems."
With oil up, investors sold shares of consumer-oriented companies, including Procter & Gamble <PG.N> , down 2.3 percent at $68.77. Shares of Target Corp <TGT.N>, the No. 2 U.S. discount retailer, dropped 4.7 percent to $50.80 after Lazard Capital Markets cut the stock to "hold" from buy."
Uncertainty about the bailout overshadowed news that Japan's largest bank, Mitsubishi UFJ Financial Group <8306.T>, planned to buy a stake in Wall Street bank Morgan Stanley <MS.N>.
Goldman Sachs <GS.N> and Morgan Stanley are abandoning their investment bank model of two decades to become bank holding companies regulated by the Federal Reserve.
Morgan Stanley shares were last up 1.8 percent to $27.68 after earlier adding more than 10 percent, but Goldman Sachs shares were down 4 percent at $124.63.
Among home builders, shares of Hovnanian Enterprises <HOV.N> declined 7.7 percent to $8.36. Meanwhile, shares of Caterpillar Inc <CAT.N> , an economic bellwether and a Dow component, lost 2.1 percent to $65.13.
Kraft Foods Inc <KFT.N>, a new member of the 30 Dow industrials, effective at Monday's opening bell, also dropped 3.5 percent to $33.48.
On Nasdaq, shares of Apple <AAPL.O> fell 4 percent to $135.26 after JPMorgan cut its price target on the iPod and iPhone maker's stock. (Additional reporting by Ellis Mnyandu and Kristina Cooke; Editing by Kenneth Barry)