(Updates to midday, changes byline)
By Cal Mankowski
NEW YORK, April 29 (Reuters) - U.S. stocks declined on Tuesday after regulators rejected a key new drug from Merck & Co Inc <MRK.N>, a Dow component and a pharmaceuticals bellwether, and a survey showed a sharp drop in consumer confidence.
Merck's 10 percent slide hurt both the Dow and the S&P 500, a day after the company said the U.S. Food and Drug Administration had spurned its new drug, Cordaptive, aimed to raise the level of HDL or "good" cholesterol. Several brokerages cut price targets on the stock.
The latest economic data increased investors' fears of recession, with consumer confidence hitting a five-year low in April, as well as signs that more homeowners are falling behind in their mortgage payments and foreclosures are rising.
The Standard & Poor's/Case Shiller home price index showed prices of existing U.S. single family homes fell further in February.
With fears of recession mounting, the Federal Reserve's comments on the economy took on particular urgency. The Fed was scheduled to begin a two-day meeting on the economy and interest rates on Tuesday, with the decision on interest ratess expected on Wednesday.
"I think a 25-basis-point cut is widely anticipated," said Al Goldman, chief market strategist at Wachovia Securities, in St. Louis. He said the stock market generally sees some selling before a Fed announcement.
"It would make everybody happy if they cut 25 basis points, and come out and say, 'that's it' for the foreseeable future," Goldman said. "That could be why the dollar has been strengthening lately and oil is down $2 today."
The Dow Jones industrial average <
> declined 38.10 points, or 0.30 percent, to 12,833.65. The Standard & Poor's 500 Index <.SPX> fell 5.46 points, or 0.39 percent, to 1,390.91. The Nasdaq Composite Index < > lost 8.99 points, or 0.37 percent, to 2,415.41.In addition to Merck's jolt from the FDA, news from two biotech companies gave investors a reason to sell some drug-related stocks.
Biotechnology companies Genentech Inc <DNA.N> and Biogen Idec Inc <BIIB.O> said studies of Rituxan did not meet the main goal of helping patients with lupus. [
]Merck shares slid 10 percent, or $4.14, to $37.30 on the New York Stock Exchange, while Genentech <DNA.N> dropped 6.1 percent to $68.68. On the Nasdaq, Biogen Idec shares declined 4.2 percent to $61.95.
The American Stock Exchange pharmaceutical index <.DRG> was down 1 percent.
In contrast, International Business Machines Corp <IBM.N> provided some positive news by raising its dividend 25 percent. IBM's stock rose 0.5 percent to $122.29.
Among home builders, shares of luxury home builder Toll Brothers <TOL.N> fell 1.8 percent to $23.41 on the NYSE.
As the impact of a faltering consumer was likely to reverberate through the broader economy, investors also sold shares of big manufacturers, including General Electric <GE.N>, whose stock fell 1.2 percent to $32.76, and Caterpillar Inc <CAT.N>, whose shares shed 1.7 percent to $81.65. (Reporting by Cal Mankowski; Additional reporting by Ellis Mnyandu; Editing by Jan Paschal)