* Brent within 3 cents of $100, highest since October 2008
* Technicals show Brent may touch $100.50
* Investors concerned Egypt unrest may spread across region (Adds fund manager comment, background on Brent-U.S. crude spread)
SINGAPORE, Jan 31 (Reuters) - Brent crude closed in on $100 a barrel on Monday on concern anti-government protests in Egypt could spark instability elsewhere in the Middle East and North Africa, a region that produces more than a third of the world's oil.
Six days of unrest in Egypt has killed more than 100 people, rocked the Middle East and rattled global investors.
Egypt is not a major oil producer but protests and demands for political change there come just two weeks after Tunisia's president was overthrown. Concern that oil-producing states in the region may face similar protests is supporting crude.
"The Egyptian situation looks to be the primary factor," said David Land, chief market analyst at CMC Markets. The market is reacting to "what this could mean in terms of stability for such a vital region for energy production," he added.
Brent rose as high as $99.97 a barrel, the highest price since Oct. 1 2008, and was up 18 cents at $99.60 at 0527 GMT. Brent is trading about $10 above U.S. crude , which on Monday added 22 cents to $89.56 a barrel.
Brent oil is expected to briefly pierce $100 per barrel and touch $100.50, based on its wave pattern, according to Reuters analyst Wang Tao.
Concern that unrest could impact the flow of oil through Egypt from the Middle East to Europe underpinned price gains.
Egypt controls the Suez Canal and the Suez-Mediterranean (SUMED) Pipeline, which between them moved over 2 million barrels per day (bpd) of crude and oil products in 2009.
The 192-km (120-mile) Suez Canal shipping choke point has so far operated as usual during the protests, with 45 to 50 ships passing through each day, a canal official said.
"There has been a reaction to what's happened in Egypt, there is no doubt about it. There is concern that could escalate into the region," said Jonathan Barratt, managing director of Commodity Broking Services in Sydney.
"It's a knee-jerk reaction. If things escalate, then the premium is substantiated. Only time will tell."
A recovery in world oil consumption has taken many by surprise, led by growth in emerging economies of Asia, the Middle East and Latin America.
Production restraints by the Organization of the Petroleum Exporting Countries have also helped lower bloated inventories in industrialised economies.
ICE Brent, the marker for waterborne oil traded across the Atlantic basin, Africa and parts of Asia, last week traded at a near-record premium of $12.50 a barrel to U.S. benchmark West Texas Intermediate <CL-LCO1=R>, a landlocked domestic stream that can get chronically disconnected from global markets.
Late on Friday, the premium receded to about $10 a barrel after data showed the U.S. economy gathered speed in the fourth quarter to regain its pre-recession peak.
"The main driver of a strong Brent is on the physical side, and Brent is still the best benchmark for oil traded on a global basis," said Tetsu Emori, a fund manager at Tokyo-based Astmax Co Ltd.
"For the very short term, the Egyptian situation is a very important factor for oil prices. People are willing to take on additional risk."
Brent crude last traded above $100 a barrel on Oct. 1, 2008, the only year in which any front-month oil futures benchmark surpassed that level.
ICE Brent first touched $100 on Feb. 26, 2008, almost two months after benchmark U.S. crude West Texas Intermediate (WTI) futures reached triple digits on Jan. 2, 2008.
A series of production snags from Norway to Alaska in January has benefited waterborne Brent crude over U.S. benchmark West Texas Intermediate, a grade delivered at the landlocked storage hub of Cushing, Oklahoma.
Oil's rally to 28-month highs has increased the pressure on OPEC to open its taps and ease inflationary pressure for major crude importers, like India and China.
OPEC ministers will discuss oil output policy on the sidelines of a conference in Saudi Arabia next month, an OPEC delegate told Reuters.
Ministers are scheduled to meet on Feb. 22 in Riyadh with their counterparts from oil consuming nations and consumer body the International Energy Agency at the International Energy Forum.
Out of OPEC's 12 members, eight are in the Middle East or North Africa: Saudi Arabia, Iran, Iraq, Kuwait, the United Arab Emirates, Qatar, Algeria and Libya. (Reporting by Alejandro Barbajosa, Randy Fabi, Rebekah Kebede and Simon Webb; Editing by Ed Lane)