* FTSEurofirst 300 breaks 6 days winning run
* Set for strongest yearly gains in a decade
By Dominic Lau
LONDON, Dec 30 (Reuters) - European shares snapped a six-day winning run on Wednesday in thin trade, with banks and drugmakers leading the fallers.
The FTSEurofirst 300 <
> closed 0.4 percent lower at 1,043.24 points, pulling back from a 15-month closing high hit on Tuesday. Volumes were about 38 percent of the index's 90-day daily average.Banks <.SX7P>, one of the best performers this year, were among the top losers, with Barclays <BARC.L>, Deutsche Bank <DBKGn.DE>, BNP Paribas <BNPP.PA>, Banco Santander <SAN.MC> and UBS <USBN.VX> down 0.9-2.4 percent.
"For the early part of next year, we are cautiously optimistic," said Joost van Leenders, an investment specialist at Fortis Investments.
"The economic recovery is discounted within the markets but further gains in corporate profit may help the markets somewhat further higher. We would not say the market is overvalued at this point."
After a dismal 2008, the FTSEurofirst 300 is up 25 percent for the year, on track for its biggest yearly gains since 1999.
Data showed on Wednesday that broad euro zone money supply posted a surprise drop in November and loans to households and firms fell for the third month running, serving a warning to the European Central Bank that it must tread carefully with its exit strategy.
However, business activity in the U.S. Midwest expanded far more than expected in December, according to the Institute for Supply Management-Chicago business barometer.
Commodity shares also gave up recent gains. BP <BP.L>, Royal Dutch Shell <RDSa.AS>, Total <TOTF.PA> and BG Group <BG.L> fell 0.4-1.4 percent.
Among miners, BHP Billiton <BLT.L>, Vedanta Resources <VED.L>, Anglo American <AAL.L> and Rio Tinto <RIO.L> fell 0.4-1.4 percent.
Kazakh copper producer Kazakhmys <KAZ.L>, however, put on 0.4 percent. The miner said it has secured a loan of up to $2.7 billion from China Development Bank and Kazakh state welfare fund Samruk-Kazyna to develop its growth projects.
Drugmakers were also weaker. GlaxoSmithKline <GSK.L>, AstraZeneca <AZN.L> and Roche <ROG.VX> dropped 0.8-1.2 percent.
Across Europe, Britain's FTSE 100 <
> eased 0.7 percent and France's CAC 40 < > lost 0.6 percent. Germany's DAX < > dropped 0.9 percent, but was still up 23.9 percent for the year after losing 40 percent in 2008.German markets will close on New Year's Eve, while those in London and Paris will have shortened trading session. They will resume trading on Monday, Jan. 4.
Alternative energy firms were in demand on Wednesday, with Q-Cells <QCEG.DE> up 2.5 percent and Vestas Wind <VWS.CO> up 2.9 percent.
Among individual movers, Petrofac <PFC.L> added 1.9 percent after the oil services firm won its first contract in Turkmenistan. (Editing by Rupert Winchester)