* FTSEurofirst 300 index down 0.3 pct
* Financials fall on writedown fears
* Oils rebound as crude hovers around $42 a barrel
By Joanne Frearson
LONDON, Jan 23 (Reuters) - European shares ended weaker on Friday, retreating for the 12th time over the past 13 sessions to hit their lowest close in six years, dragged down by financials as fears of more hefty losses in the sector deepened. The pan-European FTSEurofirst 300 <
> index of top European shares ended down 0.3 percent at 760.54 points falling to its lowest close since April 2003.Banks took the most points off the index. Barclays <BARC.L> fell 13.5 percent as concerns grew that the bank may require further capital or be nationalised. [
]"Sentiment is very fragile. People want to believe in economic recovery and want to see some light at the end of the tunnel, but they are finding it very difficult to see that when you have got a banking system which is still experiencing severe difficulties," said Darren Winder, strategist at Cazenove.
"Until they get the banking system into a situation where it can fulfill its normal obligations to the real economy and provide it with sufficient liquidity and credit, then I think people are generally going to continue to feel very nervous about the market," Winder said.
BNP Paribas <BNPP.PA>, Standard Chartered <STAN.L> and Societe Generale <SOGN.PA> were down 5.75 percent to 7.8 percent.
Insurers were in the doldrums. Swiss Re <RUKN.VX> lost 19.2 percent on worries it could make further writedowns when it reports full-year results on Feb. 19.
"Swiss Re is coming under pressure because of fears its has critical amounts of CDS (credit default swaps) on its balance sheet and that its hedges might not work," a trader said.
A Swiss Re spokeswoman said the company did not comment on market rumours.
German chemical group Wacker Chemie <WCHG.DE> fell 4.8 percent following a gloomy outlook from U.S. peer MEMC Electronic Materials <WFR.N> which forecast weak first-quarter revenue.
Across Europe, the FTSE 100 <
> index was up 0.01 percent, Germany's DAX < > was down 1 percent and France's CAC 40 < > was down 0.7 percent.OILS REBOUND
Energy stocks rebounded from earlier falls to top the index risers as crude <CLc1> stayed above $42 a barrel.
BG Group <BG.L>, Royal Dutch Shell <RDSb.L> and Total <TOTF.PA> were 1.5-2.8 percent higher.
Drug makers were also on the up. Germany's Merck KGaA <MRCG.DE> surged 8.6 percent after it pulled ahead of Novartis <NOVN.VX> in the race to develop the first pill for multiple sclerosis.
"This is a very important drug for Merck, with expected sales of more than 1 billion euros, which is boosting the share price," a trader said.
AstraZeneca was up 3.6 percent as analysts expect it to report strong fourth-quarter earnings on Jan. 29 boosted by sales of cholesterol drug Crestor following good study results. [
]Lift maker Kone <KNEBV.HE> soared 5.5 percent after the group reported solid fourth-quarter earnings and said orders came in as expected and targeted at least flat earnings and sales in 2009. [
]And Cintra <CCIT.MC> gained 3.7 percent after it said its 90 percent-owned consortium has won a highway contract in Poland for a total investment of 2.1 billion euros. [
](Reporting by Joanne Frearson; Editing by Sharon Lindores)
(joanne.frearson@thomsonreuters.com; +44 207 542 2773, Reuters Messaging:joanne.frearson.thomsonreuters.com@reuters.net)