* FTSEurofirst 300 down 0.6 percent
* Banking stocks retreat after Lehman losses
* Oils mixed, miners slip
By Brian Gorman
LONDON, Sept 10 (Reuters) - European shares closed lower on Wednesday, as banks suffered on concerns about the financial sector's health and after Lehman Brothers <LEH.N> posted a record quarterly loss of about $4 billion.
The FTSEurofirst 300 <
> index of top European shares fell 0.64 percent to 1,148.23 points after falling more than 1 percent earlier in the day. The pan-European index is down about 24 percent so far this year.Lehman said it planned to sell a majority stake in its investment management division and spin off commercial real estate assets as the struggling U.S. investment bank fought to raise capital. [
]Banks were the top negative weight on the European index, with Natixis <CNAT.PA> falling 6 percent, Credit Agricole <CAGR.PA> losing 4.8 percent, Dexia <DEXI.BR> down 4.2 percent, Royal Bank of Scotland <RBS.L> dropping 3.6 percent, Barclays <BARC.L> slipping 5.3 percent and UBS <UBSN.VX> shedding more than 4 percent.
"There's no direct link between Lehman's problems and Europe, but this is the normal financial reaction," said Christophe, strategist at Paris-based Kepler Equities.
"It's more bad news. It shows that the fall-out from the credit crunch is far from over."
Concerns about the financial sector's health continued. Credit Agricole, France's biggest retail bank, said it would cut 500 jobs at Calyon, its investment banking unit that has been badly hit by the global credit crunch.
European economic growth, hit by high commodity prices, financial market turmoil and the end of a decade-long housing boom, has slowed sharply and continues to do so, the European Commission said. [
]"Nothing about the configuration of the economy has changed. We still have to face a sluggish environment," Donay said, referring to the U.S. and European economies.
In industry news, Deutsche Bank <DBKGn.DE> was close to clinching a stake in rival Deutsche Postbank <DPBGn.DE> in a deal that could come later this week, sources with direct knowledge of the matter said on Wednesday. [
]Postbank was up 4.1 percent, while Deutsche Bank fell 1.7 percent.
Across Europe, Britain's FTSE <
> fell 0.9 percent, Germany's DAX < > was down 0.4 percent and France's CAC < > dropped 0.2 percent.MINERS SLIP, OILS MIXED
Miners also suffered on concerns about lower demand for metals. BHP Billiton <BLT.L>, Anglo American <AAL.L>, Vedanta Resources <VED.L>, Lonmin <LMI.L>, Kazakhmys <KAZ.L>, Xstrata <XTA.L>, Antofagasta <ANTO.L> and Rio Tinto <RIO.L> fell between 0.3 and 8.8 percent.
Oil stocks were mixed, having tracked volatile oil prices during the session. Crude oil <CLc1> was last down 0.4 percent.
BP <BP.L> closed 1 percent lower, while StatoilHydro <STL.OL> was 2.3 percent higher after Sanford Bernstein reiterated its overweight stance on the company. Total <TOTF.PA> was up 0.3 percent.
Among other stocks, French drugmaker Sanofi-Aventis <SASY.PA> rose 7.2 percent to top the gainers list, after the company named GlaxoSmithKline <GSK.L> executive Chris Viehbacher as its new chief executive officer.
GlaxoSmithKline <GSK.L> rose nearly 2 percent. The company was paying as much as $1.5 billion to develop new drugs against inflammatory disease with Anglo-German biotech company Cellzome, the two groups said.
Novartis <NOVN.VX>, a peer, was up 1.4 percent.
Finnish paper company Stora Enso <STERV.HE> was the second-biggest gainer on the index, rising 5.7 percent, after it announced plans to cut 1,700 jobs and said it would take a writedown of about 280 million euros as it tries to cope with a planned increase in Russian wood duties and an ailing market. (Editing by Richard Hubbard)