* FTSEurofirst 300 falls 0.2 percent
* Banks fall after UBS results
* Rio Tinto leads miners lower
By Brian Gorman
LONDON, April 15 (Reuters) - European shares closed lower on Wednesday, snapping a three-day winning run, with UBS <UBSN.VX> <UBS.N> leading banks down after making a first-quarter loss, and oils and miners falling.
The FTSEurofirst 300 <
> index of top European shares fell 0.2 percent to 788.21 points. The index has fallen 5.3 percent this year after plunging 45 percent in 2008, but is up 22.1 percent from the record low of March 9.Wall Street was mixed as European bourses were closing. U.S. investors absorbed data that mostly gave downbeat signals about the depth of the recession in the world's biggest economy.
"The market is catching its breath. There is a cooling of sentiment, as some of the data shows there is a protracted slowdown, dashing hopes of a quick recovery," said Gerhard Schwarz, head of global equity strategy at UniCredit in Munich.
UBS, which rose 10 percent on Tuesday, fell 6.9 percent after Switzerland's largest bank made a first-quarter loss of nearly 2 billion Swiss francs ($1.74 billion), and said it will reduce its workforce by another 11 percent. [
]BNP Paribas <BNPP.PA>, Banco Santander <SAN.MC>, Credit Agricole <CAGR.PA>, Deutsche Bank <DBKGn.DE>, HSBC <HSBA.L> and Standard Chartered Bank <STAN.L> closed between 1.5 percent and 4.3 percent lower.
Miners lost ground after Rio Tinto <RIO.L> said its first-quarter aluminium output fell 6 percent, mostly due to curtailments in Europe. Rio fell 5.2 percent.
Other miners also fell, even as most metals prices rose. BHP Billiton <BLT.L>, Anglo American <AAL.L>, Antofagasta <ANTO.L> and Xstrata <XTA.L> between 3.1 percent and 7.5 percent.
U.S. industrial production fell an unexpectedly sharp 1.5 percent in March, U.S. Federal Reserve data showed, capping a brutal quarter as businesses pared orders and cut inventory in a deepening recession. [
]U.S. consumer prices fell in March and recorded their first 12-month drop since 1955, as slumping demand pushed down energy and food costs.
OILS FALL
Energy shares also lost ground. Crude prices <CLc1> initially fell after U.S. government data showed inventories rose to their highest since 1990, but recovered later to more than $50 a barrel.
BP <BP.L>, ENI <ENI.MI>, Repsol <REP.MC>, Total <TOTF.PA> fell between 1 percent and 3.6 percent.
Traditionally defensive drugmakers rose. Shire <SHP.L> was up 2.7 percent and GlaxoSmithKline <GSK.l> gained 1.6 percent.
Sanofi-Aventis <SASY.PA> rose 1.6 percent after saying it was buying private U.S. cancer specialist BiPar Sciences Inc. for up to $500 million in the latest bolt-on acquisition by the French drugmaker.
Tobacco, another defensive sector, gained with British American Tobacco <BATS.L> and Imperial Tobacco <IMT.L> up 4.8 percent and 3.6 percent respectively.
Anglo-Dutch publisher Reed Elsevier <REL.L> rose 5.9 percent after Goldman Sachs added the company to its "conviction buy" list after the stock hit a four-month low on Tuesday.
"We believe its discount valuation is extreme and the stock presents an excellent mean reversion opportunity," the broker said.
Nokia <NOK1V.HE> fell 3.8 percent ahead of first-quarter results on Thursday.
"The earnings season should not be a major threat to the equity market unless there are profit warnings, as expectations are low enough," said Schwarz.
Across Europe, Britain's FTSE 100 <
>, Germany's DAX < > and France's CAC-40 < > fell between 0.2 percent and 0.5 percent. (Additional reporting by Atul Prakash; Editing by Andrew Macdonald)