* FTSE down 0.3 percent
* Miners retreat with metals ahead of U.S. GDP
* Shire rises on Q3 results, positive drug study
By David Brett
LONDON, Oct 29 (Reuters) - Miners dragged Britain's top shares lower on Friday, as metals prices waned ahead of U.S. third-quarter growth numbers, outpacing strength in defensive stocks with drugmaker Shire gaining after bullish results.
By 1056 GMT, the FTSE 100 <
> was 17.95 points, or 0.3 percent, lower at 5,662.87, having closed up 0.6 percent on Thursday.Miners <.FTNMX1770> continued their ebb and flow of recent days giving back part of Thursday's advance, with Xstrata <XTA.L> and Rio Tinto <RIO.L> the worst off, down 3.1 percent and 2.2 percent respectively.
Investors were awaiting the advance reading for U.S. third-quarter gross domestic product (GDP), due at 1230 GMT, with quarterly growth of 2.0 percent forecast. [
]"Generally we have seen traders turn more cautious by removing elements of risk from their portfolios as we head into the afternoon and the important US GDP figure," Joshua Raymond, Market Strategist, City Index said.
"There is a slight worry that US GDP could track a similar tone to that of the UK's third quarter GDP announced earlier this week by proving to be more resilient than anticipated."
U.S. futures <DJc1> <SPc1> <NDc1> pointed to a weaker start on Wall Street on Friday, ahead of the GDP figure.
DEFENSIVE SUPPORT
Perceived defensive shares littered the FTSE 100 leaderboard as investors switched out of riskier assets such as miners and banks.
Pharmaceutical firm Shire <SHP.L> was a top riser, up 1.6 as it reported an upbeat third-quarter performance, and positive results from a phase 2 study of vyvanse in patients who have had residual symptoms of depression.
Utility firm Centrica <CNA.L> rose 2.4 percent, while United Utilities <UU.L> and Scottish & Southern Energy <SSE.L> added 1.7 and 1.6 percent respectively.
Energy stocks <.FTNMX0530>, which rose on Thursday after above-forecast results from Royal Dutch Shell <RDSa.L>, were in favour.
BP <BP.L> rose 0.3 percent after a U.S. presidential panel said contractor Halliburton Co. <HAL.N> used flawed cement in the Gulf of Mexico well that caused the worst offshore oil spill in U.S. history. [
]Royal Dutch Shell <RDSa.L> climbed 0.9 percent, while BG Group <BG.L> added 0.3 percent ahead of third-quarter earnings from U.S. peer Chevron <CVX.N>.
There was support for insurers, buoyed by a strong performance from AIA Group Ltd <1299.HK> at its flotation in Hong Kong.
AIA shares surged over 17 percent on their debut on Friday as investors, chasing exposure to Asia's fast-growing life insurance business, piled into the record offering. [
]UK insurer Aviva <AV.L> was up 2.0 percent.
British Airways <BAY.L> was among the top FTSE 100 <
> fallers, off 2.7 percent, after the airline posted first-half results, with investors taking profits after a good run in the share price, and as economic uncertainty remains. (Editing by Sharon Lindores)