By Sitaraman Shankar
LONDON, April 23 (Reuters) - European shares rose early on Wednesday, led by Belgian drugmaker UCB <UCB.BR>, which gained on a key regulatory approval, while robust oil and metal prices lifted commodity stocks and acquisition talk boosted telecoms.
At 0802 GMT, the FTSEurofirst 300 <
> index of top European shares was up 0.5 percent at 1,310.55 points.UCB topped the leader board, soaring 26 percent after its Cimzia drug for bowel disorder Crohn's disease won U.S. regulatory approval about a year earlier than envisaged.
Miners and energy stocks were the top weighted gainers on the index, as crude prices stayed around $118 a barrel and copper ticked up.
Lonmin <LMI.L>, Antofagasta <ANTO.L> and Vedanta <VED.L> all rose more than 1.2 percent, while BP <BP.L> rose 0.6 percent and Total <TOTF.PA> gained 1.2 percent.
Telecoms group KPN <KPN.AS> rose 2.9 percent on a newspaper report that Spanish rival Telefonica <TEF.MC> was planning a bid for it. Telefonica declined to comment, apart from saying that its priority was to cut debt and raise its dividend.
Chipmaker Infineon <IFXGn.DE> jumped 5.5 percent on market talk of private equity interest. It declined to comment.
The company earlier said it expected third-quarter sales to be flat or slightly lower this year.
"The key issue over the next week is whether analysts reset expectations. As U.S. and UK GDP weakens, investors have still not factored in a slowdown, and they may start doing this," said Justin Urquhart Stewart, investment director at 7 Investment Management.
"I hope companies give us weaker outlook statements, which are more realistic. This is a good time to get bad news out, to reset expectations," he said.
Britain's FTSE 100 <
> rose 0.4 percent, while Germany's DAX < > gained 0.5 percent and France's CAC < > rose 0.8 percent, led by a 3-percent gain in building material maker St Gobain <SGOB.PA>.The group stuck to its 2008 earnings growth targets despite posting lower first quarter sales late on Tuesday.
RESULTS KEY
Later in the session, the focus shifts to results from drugmaker GlaxoSmithKline <GSK.L>. For an analyst poll, double click on [
].Urquhart Stewart said that the market would look for solid earnings from the group, but added that it had still to give investors confidence about its new drug pipeline.
Despite question marks over the efficiency of their research programmes, pharmaceutical stocks have outdone many sectors this year, benefiting from general investor risk aversion, but Urquhart Stewart said other defensives were a good bet.
"Among defensives, the major gainers are likely to be the discount grocery companies such as Tesco <TSCO.L>, which are gaining from higher food prices," he said.
Stocks were also underpinned by the euro coming off after ECB governing council member Christian Noyer indicated that eurozone rates could move in either direction.
The FTSEurofirst has risen 3.7 percent so far this month, putting it on line for its best month since September 2005, but after a torrid first quarter where it lost 16 percent, driven by massive bank writedowns stemming from credit market problems.
These market ructions have prompted calls for a revamp at Swiss bank UBS <UBSN.VX>, and a record rights issue at Royal Bank of Scotland. Both stocks stayed in focus ahead of shareholder meetings later in the day.
RBS was down 2.9 percent and UBS down 0.3 percent.
U.S. stocks were expected to open higher based on index futures. Overnight, search engine group Yahoo <YHOO.O> posted a better-than-expected quarterly profit. (Editing by Paul Bolding)